I know phenobarbital causes an increase in alkaline phosphatase, however my research says alk phos…

I know phenobarbital causes an increase in alkaline phosphatase, however my research says alk phos is not the indicator for liver disease. My dog’s seizures are well controlled on phenobarb but his alk phos is off the wall. He has no symptoms of liver disease. At this point, I would just assume he not have labs drawn anymore unless I knew which ones would yield the most accurate information. Any suggestions? Thanks.

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Krista Magnifico
7 years ago

Hello Lynne, I apologize for the delay. The answer was sent a few hours after you asked it but then it appears it never reached you..I sincerely apologize for this… I think that this is a very good question, however, I don’t want to speak for the veterinarian managing your dogs case, so I will give the advice that I would give for one of my clients. It is very common to see an increase in alkaline phosphatase (we call it alk phos), when a pet is on phenobarbital. It usually does not indicate liver disease. The alk phos usually… Read more »