she is usually a very affectionate cat especially with me, but recently she has become…

she is usually a very affectionate cat especially with me, but recently she has become very distant and cry a lot which is very loud, she has also lost fur on her back legs and at the base of her tail. I apply flea drops every 4 weeks and I have recently sprayed the hose just invade fleas where the issue, out other cat Tilly is perfectly fine so I double fleas are the issue, any help or advice please?
Thanks for your time

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